Sheldon is an unincorporated community and census-designated place in Beaufort County, South Carolina, United States. It was first listed as a CDP in the 2020 census with a population of 579. A rural area in character, Sheldon was primarily a common gathering area for various plantation owners and slaves prior to the Civil War. It is renowned for the Old Sheldon Church Ruins. Several hunt clubs and gated communities are located in the area.