Southaven is a city in DeSoto County, Mississippi, United States. It is a principal city in Greater Memphis. The 2020 census reported a population of 54,648, making it the 3rd most populous city in Mississippi and the largest suburb of Memphis by population. Southaven surpassed Bartlett, TN as largest suburb with a population of 56,851 according to 2023 census estimates. Southaven is traversed north to south by the I-55/I-69 freeway.