Heroica Ciudad de Huajuapan de León is a city with a surrounding municipality located in the northwestern part of the Mexican state of Oaxaca. It is part of the Huajuapan District in the north of the Mixteca Region. The municipality has a population of 78,318, the sixth-largest community in the state in population. It is located at the intersection of Federal Highways 125 and 190. The name of Huajuapan comes from the Nahuatl words huaxin= huaje, ohtli= road, and apan= river.