Byrnedale is an unincorporated community and census-designated place in Elk County, Pennsylvania. As of the 2020 census, the population was 382. It is located in Jay Township, in the valley of Kersey Run, and is bordered to the south by Weedville. Pennsylvania Route 255 passes through Byrnedale, leading north 11 miles to St. Marys and southwest 20 miles to DuBois.