Santos is a municipality in the Brazilian state of São Paulo, founded in 1546 by the Portuguese nobleman Brás Cubas. It is partially located on the island of São Vicente, which harbors both the city of Santos and the city of São Vicente, and partially on the mainland. It is the main city in the metropolitan region of Baixada Santista. The population is 433,966 (2015 est.) in an area of 280.67 km². The city is also home to the Coffee Museum, where coffee prices were once negotiated.