Seiling is a city in Dewey County, Oklahoma, United States. The population was 850 at the 2020 census. The town was named in 1899 for Louis Seiling, a local store owner who had acquired a homestead in the Cheyenne-Arapaho land run of April 1892. The Hobson Town and Improvement Company established a town called Hobson, but the name was changed to Seiling in January 1899. It incorporated in 1909. Seiling is now the largest city in Dewey County.