San Antonio de Oriente is a municipality in the Honduran department of Francisco Morazán. Population as of 2015 is 15,299. The first occupants came in 1660 in the village Mineral de San Antonio that is 4 km away from the present town. Nowadays it is called San Antonio Yusguare. A kilometre west of San Antonio de Oriente lies San Antonio Ocidente. San Antonio de Oriente lies 28 km from Tegucigalpa, high in the mountains.