Sabine Parish is a parish located in the U.S. state of Louisiana. As of the 2020 census, the population was 22,155. The parish seat and largest town is Many. Sabine was one of five parishes created in as many weeks by the Louisiana State Legislature March 27, 1843. It was created from Natchitoches Parish with the Sabine River as the international boundary between the United States and the Republic of Texas as the western boundary.