Boissevain is an unincorporated community, census-designated place, and former coal town in Tazewell County, Virginia, United States. It was defined as a census-designated place at the 1950 United States Census under the spelling Boissevaine, when it had a population of 1,197. It did not reappear again as a CDP until the 2020 census with a population of 457. In February 1932 38 men lost their lives in a coal mine explosion.