Jacobs is a neighborhood on the south side of Louisville, Kentucky, in the United States. Its boundaries are Berry Boulevard to the north, Taylor Boulevard to the east, the I-264 to the south, and Seventh Street to the west. It was developed as Jacob's Addition in 1892 after the opening of nearby Jacob's Park and named for four-time Louisville mayor Charles Donald Jacob. The area housed a veteran's hospital, Nichols General Hospital, until 1952.