Chesapeake is a village in Lawrence County, Ohio, United States. The population was 765 as of the 2020 census. It lies across the Ohio River from Huntington, West Virginia, at the mouth of Symmes Creek. The Robert C. Byrd Bridge across the Ohio River connects Chesapeake to Huntington's downtown area. At one time, this was the only bridge connection across the Ohio River linking Ohio to Huntington.