Ripley County is a county in the Ozarks of Missouri. At the 2020 census, it had a population of 10,679. The largest city and county seat is Doniphan. The county was officially organized on January 5, 1833, and is named after Brigadier General Eleazer Wheelock Ripley, a soldier who served with distinction in the War of 1812. The original area included what would later become Oregon, Howell, Shannon and Carter counties. The historic Natchitoches Trail passes through Ripley County.