Gmina Pyrzyce is an urban-rural gmina in Pyrzyce County, West Pomeranian Voivodeship, in north-western Poland. Its seat is the town of Pyrzyce, which lies approximately 38 kilometres south-east of the regional capital Szczecin. The gmina covers an area of 204.40 square kilometres, and as of 2006 its total population is 19,515.