Leona Valley is a census-designated place located in the geographic Leona Valley of northern Los Angeles County, California, in the transition between the Sierra Pelona Mountains and Mojave Desert, just west of Palmdale and the Antelope Valley. The population was 1,607 at the 2010 census. Leona Valley is best known for its agriculture, particularly cherries and wine grapes. The town of Leona Valley holds its annual Leona Valley Cherry Festival in honor of its agricultural heritage.