Brandywine is the name of an unincorporated area in Prince George's County, Maryland, United States, that refers both to a census-designated place and a zip code area which is much larger, whose areas overlap. The population of Brandywine at the 2020 U.S. Census was 10,550 for the CDP, and the population of ZIP code 20613 was 11,860 in 2010. Brandywine is in the southernmost area of Prince George’s County, surrounded by a rural setting. It is in the Southern Maryland region.