Mousehole is a village and fishing port in Cornwall, England, UK. It is approximately 2.5 miles south of Penzance on the shore of Mount's Bay. The village is in the civil parish of Penzance. An islet called St Clement's Isle lies about 350 metres offshore from the harbour entrance. Mousehole lies within the Cornwall Area of Outstanding Natural Beauty. 27% of Cornwall has AONB designation, with the same status and protection as a National Park.