San Francisco de Milagro is a city located in Guayas, Ecuador. It is the seat of Milagro Canton. Milagro is the fourth largest city in the province of Guayas. As of the census of 2022, there were 195,943 people residing within the canton limits. Denisse Robles, mayor, pledged to get a city railway station and to improve the coverage of Milagro's drinking water. She was elected the mayor of Milagro in 2014 with 38% of the vote, finishing ahead of the incumbent mayor Francisco Asan.