Sambuca di Sicilia is a comune in the Province of Agrigento in the Italian region Sicily, located about 68 kilometres southwest of Palermo and about 89 kilometres northwest of Agrigento. It is one of I Borghi più belli d'Italia. Sambuca di Sicilia borders the following municipalities; Bisacquino, Caltabellotta, Contessa Entellina, Giuliana, Menfi, Santa Margherita di Belice, and Sciacca.