Greensboro is a city in and the county seat of Guilford County, North Carolina, United States. It is the 3rd-most populous city in North Carolina after Charlotte and Raleigh, the 69th-most populous city in the United States, and the most populous city in the Piedmont Triad metropolitan region. At the 2020 census, its population was 299,035; at the 2022 census estimate, its population was 301,115.