Sisquoc is a census-designated place in Santa Barbara County, California located east of U.S. Route 101 about 15 miles southeast of Santa Maria and 5 miles south of Garey. The ZIP Code is 93454, and the community is inside area code 805. Sisquoc has a fire station, a church, a Preschool-8 school and a store. It has a micro-climate with mild weather year-round. The population was 183 at the 2010 census.