Boone is a city in Des Moines Township, and county seat of Boone County, Iowa, United States. It is the principal city of the Boone, Iowa Micropolitan Statistical Area, which encompasses all of Boone County. This micropolitan statistical area, along with the Ames, Iowa Metropolitan Statistical Area comprise the larger Ames-Boone, Iowa Combined Statistical Area. The population of the city was 12,460 at the 2020 census.