Borghetto di Borbera is a comune in the Province of Alessandria in the Italian region Piedmont, located about 110 kilometres southeast of Turin and about 35 kilometres southeast of Alessandria. Borghetto di Borbera borders the following municipalities: Cantalupo Ligure, Dernice, Garbagna, Grondona, Roccaforte Ligure, Sardigliano, Stazzano, and Vignole Borbera.