Tuscumbia is a city in, and the county seat of, Colbert County, Alabama, United States. As of the 2020 census, the population was 9,054. The city is part of The Shoals metropolitan area. Tuscumbia was the hometown of Helen Keller, who lived at Ivy Green. Several sites in the city are listed on the National Register of Historic Places, especially in the Tuscumbia Historic District. The city is also the site of the Alabama Music Hall of Fame.