Mistissini is a Cree town located in the south-east corner of the largest natural lake in Quebec, Lake Mistassini (120 km long by 30 km wide). The town is inside the boundaries of the Baie-James Municipality and is the largest Cree community, with a population of 3,427 people in 2011. The surface area of the town is 1380 km². Mistissini is part of the Grand Council of the Crees (Eeyou Istchee) and the Cree Regional Authority.