New Salisbury is an unincorporated census-designated place in Jackson Township, Harrison County, Indiana, United States. As of the 2010 census it had a population of 613. The community is centered on the intersection of State Highway 135 and State Highway 64, about 7 miles away from Corydon, the county seat. Businesses in New Salisbury include two gas stations, two grocery stores, a drug store, a bank, a veterinarian's office, doctor offices, a transport company, and a manufacturing company.