Piedmont is a city in Calhoun and Cherokee counties in the U.S. state of Alabama. The population was 4,400 at the 2020 census. It is included in the Anniston-Oxford, Alabama Metropolitan Statistical Area. The city is approximately one and a half hours west of Atlanta, Georgia via US Hwy 278, one and a half hours northeast of Birmingham, 20 minutes north of Anniston, Alabama via AL-21, and 25 minutes east of Gadsden, Alabama via US Hwy 278.