Mesuji Regency is a regency of Lampung Province, on Sumatra island, Indonesia. It was created on 29 October 2008 from what were previously the most northern districts of Tulang Bawang Regency. It has an area of 2,200.51 km2 and a population of 187,286 people at the 2010 census and 227,518 at the 2020 census; the official estimate as at mid 2023 was 237,935. The regency seat is the town of Mesuji.