Lusk is a town and the county seat of Niobrara County, Wyoming. It is located in the High Plains. The town was founded in July 1886, by Frank S. Lusk, a renowned Wyoming rancher, partner in the Western Live Stock Company, and stockholder in the Wyoming Central Railway. Cattle ranching remains the primary industry in the town of Lusk. The population was 1,541 at the 2020 census.