Damascus is an unincorporated community and census-designated place in southern Mahoning and northern Columbiana counties in the U.S. state of Ohio. As of the 2020 census, it had a population of 418. The community lies at the intersection of U.S. Route 62 and State Routes 173 and 534.The community is located in southwestern Goshen Township in Mahoning County and northwestern Butler Township in Columbiana County. Damascus has a post office, with the ZIP code of 44619.