Pierce City, formerly Peirce City, is a city in southwest Lawrence and northwest Barry counties, in southwest Missouri, United States. The population was 1,292 at the 2010 census. In 2010, the town annexed property along Route 97 into Barry County to a point just north of U.S. Route 60. It was estimated to have a population of 1,309 by the City of Pierce City as of July 1, 2019.