Titusville is a city in the far eastern corner of Crawford County, Pennsylvania, United States. The population was 5,262 at the 2020 census. Titusville is known as the birthplace of the American oil industry and for a number of years was the leading oil-producing region in the world. It was also notable for its lumber industry, including 17 sawmills, as well as its plastic and toolmaking industries. It is part of the Meadville micropolitan area.