Upson is an unincorporated community located in Iron County, Wisconsin, United States. Upson is located at the junction of Wisconsin Highway 77 and Wisconsin Highway 122 12 miles southwest of Hurley, in the town of Anderson. Upson had an Air Defense Command radar station of the Permanent System radar network and a post office, which closed on March 16, 1985. One of the three people that surveyed the area was named Upson.