Littlefield is an unincorporated community and census-designated place in Mohave County, Arizona, United States, that is located in the Arizona Strip region. As of the 2020 census, its population was 256, a decline from the figure of 308 tabulated in 2010. It lies just south of Interstate 15, next to the Virgin River, approximately 10 miles northeast of Mesquite, Nevada. Littlefield is located in the 86432 ZIP Code.