Tirúa is a Chilean commune and town in Arauco Province, Biobío Region. The 2010 Chile earthquake led to a permanent uplift of Tirúa of about 180 cm above sea level, the highest recorded uplift related to the earthquake. This caused a large islet to form at the mouth of Tirúa River next to the town. The Misión Jesuita Mapuche is based in Tirúa.