Wadesville is an unincorporated area in northern Center Township, Posey County, in the U.S. state of Indiana. It lies along State Road 66 northeast of the city of Mt. Vernon, the county seat of Posey County. Although Wadesville is unincorporated, it has a post office, with the ZIP code of 47638. As of 2023 the U.S. Census Bureau had established a census-designated place for this settlement.