Butchertown is a neighborhood just east of downtown Louisville, Kentucky, United States, bounded by I-65, Main Street, I-71, Beargrass Creek and Mellwood Avenue. The Butchertown Historic District is a 50 acres part which was listed on the National Register of Historic Places in 1976. It includes the 1914-built Beaux Arts Stockyard Exchange Building designed by D.X. Murphy and Brother.