Santa Cruz is a district in the northern part of the City of Manila, Philippines, located on the right bank of the Pasig River near its mouth, bordered by the districts of Tondo, Binondo, Quiapo, and Sampaloc, as well as the areas of Grace Park and Barrio San Jose in Caloocan and the district of La Loma in Quezon City. The district belongs to the 3rd congressional district of Manila.