Hopland is a census-designated place in Mendocino County, California, United States. It is located on the west bank of the Russian River, 13 miles south-southeast of Ukiah, in the Sanel Valley, at an elevation of 502 feet. The population was 661 at the 2020 census, down from 756 at the 2010 census. Hopland is located at the start of the North Coast or Redwood Coast region of Northern California. It is 100 miles north of San Francisco along U.S. Route 101 and a 30-minute drive to California's largest natural lake, Clear Lake.