Bliss is the largest hamlet and a census-designated place in the town of Eagle, Wyoming County, New York, United States. As of the 2010 census, it had a population of 527. The community is in southern Wyoming County, in the north and central part of the town of Eagle. It is bordered to the north by the town of Wethersfield. Bliss is in the valley of Wiscoy Creek where it is joined by its North Branch. Wiscoy Creek flows east and south to the Genesee River, a tributary of Lake Ontario.