Bison is an unincorporated community and census-designated place located on US Highway 81 in Garfield County, Oklahoma, United States, consisting of a 30-acre town plat. As of the 2010 census, it had a population of 65.The community was named for nearby Buffalo Springs, a historic stagecoach stop and a watering hole on the Chisholm Trail located about a mile north of Bison. Bison is home to a Catholic community, part of St. Joseph's parish under the Archdiocese of Oklahoma City.