Independence is a town located in and the county seat of Grayson County, Virginia. At the 2020 U.S. census, it had a population of 1,001. It is situated on Virginia's Crooked Road, a heritage trail celebrating the musical heritage of Southwest Virginia. The town and county are noted for the original red brick 1908 Courthouse at the corner of Main Street and Independence Avenue, site of the annual July 4th Celebration and autumn Mountain Foliage Festival.