Pittsboro is a town in Chatham County, North Carolina, United States. The population was 3,743 at the 2010 census and 4,537 at the 2020 census. It is the county seat of Chatham County. The town was established in the late 18th century, shortly after the American Revolution, as the county seat for the newly formed Chatham County. In the years leading up to the American Civil War, the economy was dominated by small-scale farms that relied heavily on enslaved labor.