Casaletto Lodigiano is a comune in the Province of Lodi in the Italian region Lombardy, located about 20 kilometres southeast of Milan and about 13 kilometres west of Lodi. Casaletto Lodigiano borders the following municipalities: Cerro al Lambro, San Zenone al Lambro, Bascapè, Salerano sul Lambro, Caselle Lurani.