Sanibel is an island and city in Lee County, Florida, United States. The population was 6,382 at the 2020 census, down from 6,469 at the 2010 census. It is part of the Cape Coral-Fort Myers, Florida Metropolitan Statistical Area. The island, also known as Sanibel Island, constitutes the entire city. It is a barrier island—a collection of sand on the leeward side of the more solid coral-rock of Pine Island. Most of the city proper is at the island's eastern end.