Nueces County is located in the U.S. state of Texas. As of the 2020 census, the population was 353,178, making it the 16th-most populous county in the state. The county seat is Corpus Christi. The county was formed in 1846 from portions of San Patricio County and organized the following year. It is named for the Nueces River, which marks the county's northwestern boundary with San Patricio County before emptying into its mouth at Nueces Bay north of the port of Corpus Christi.