Madison County is a county in the U.S. state of Illinois. It is a part of the Metro East in southern Illinois. According to the 2020 census, it had a population of 264,776, making it the eighth-most populous county in Illinois and the most populous in the southern portion of the state. The county seat is Edwardsville, and the largest city is Granite City. Madison County is part of the Metro East region of Greater St. Louis.