Cloutierville is an unincorporated community in Natchitoches Parish, Louisiana, United States. It lies approximately 20 miles south of the city of Natchitoches on the Cane River. The community is part of the Natchitoches Micropolitan Statistical Area, off exit 119 of Interstate 49. This is a homeland of many multiracial Louisiana Creole people. It is in the NPS Cane River National Heritage Area.