Whitesboro is an unincorporated community and census-designated place in Le Flore County, Oklahoma, United States. The population was 250 as of the 2010 census. A post office opened at Whitesboro, Indian Territory on April 14, 1902. The community took its name from Paul White, an early-day settler. At the time of its founding, Whitesboro was located in Wade County, a part of the Apukshunnubbee District of the Choctaw Nation.