Manlius is a village in Onondaga County, New York, United States, and a southeast suburb of Syracuse. As of the 2020 census, the population was 4,662. The Village of Manlius is located near the southern boundary of the Town of Manlius. An area of approximately three blocks within the village, running along Seneca Street and parallel to Pleasant Street, is listed on the National Register of Historic Places as the Manlius Village Historic District.