Reidsville is a city in Rockingham County in the U.S. state of North Carolina. At the 2020 census, the city had a total population of 14,583. Reidsville is included in the Greensboro–High Point Metropolitan Statistical Area of the Piedmont Triad. Reidsville was established in the early 19th century as an outpost and stop on the stage line that ran between Salisbury, North Carolina, and Danville, Virginia, and was originally known as Wright's Crossroads.